Apo B/Apo A-I Ratio is Statistically A Better Predictor of Cardiovascular Disease (CVD) than Conventional Lipid Profile: A Study from Kathmandu Valley, Nepal
Published: February 1, 2014 | DOI: https://doi.org/10.7860/JCDR/2014/.4000
Hem Kumar Tamang, Uddhav Timilsina, Khelanand Prasad Singh, Sanjit Shrestha, Ramendra Kumar Raman, Pujan Panta, Preeti Karna, Laxmi Khadka, Chandika Dahal
1. Lecturer, Department of Biochemistry, Kantipur Dental College Teaching Hospital, Dhapasi, Basundhara, Kathamandu, Nepal.
2. PhD Scholar, Department of Life Sciences and Biotechnology, South Asian University, New Delhi, India.
3. Lecturer, Department of Biochemistry, Institute of Medicine (TUTH), Maharajgunj, Kathmandu, Nepal.
4. Medical Laboratory Technologist, Department of Pathology, Kathmandu Model Hospital, Exhibition Road, Kathmandu, Nepal.
5. Lecturer, Department of Anatomy, Kantipur Dental college Teaching Hospital, Dhapasi, Basundhara, Kathmandu, Nepal.
6. Faculty, Department of Medical Laboratory Technology, Nobel College, Sinamangal, Kathmandu, Nepal.
7. Faculty, Department of Medical Laboratory Technology, Nobel College, Sinamangal, Kathmandu, Nepal.
8. Faculty, Department of Medical Laboratory Technology, Nobel College, Sinamangal, Kathmandu, Nepal.
9. Faculty, Department of Medical Laboratory Technology, Nobel College, Sinamangal, Kathmandu, Nepal.
Correspondence
Dr. Hem Kumar Tamang,
Lecturer, Department of Biochemistry, Kantipur Dental College Teaching Hospital, Dhapasi, Basundhara, Kathmandu, Nepal.
Phone: 977-9818104892, E-mail: helosha@gmail.com
Background: Apo B and Apo A-I, are structural and functional components of lipoprotein particles that serve as transporters of cholesterol. The apo B/apo A-I ratio reflects the cholesterol transport and has been shown to be strongly related to risk of Myocardial infarction, stroke and other Cardiovascular manifestations.
Materials and Methods: Forty five participants with Cardiovascular Disease (CVD) and forty four healthy participants were included from different locations of Kathmandu valley, Nepal. Fasting blood samples were collected from ante-cubital vein and serum samples were used for lipid parameters, apo B and apo A-I levels measurement.
Results: Statistically significant differences were found for apo B/apo A-I ratio, HDL-c and apo B between the groups. The other lipid parameters and lipid ratios such as total cholesterol, triglyceride, low density lipoprotein, TC/HDL-c, TG/HDL-c and LDL-c/HDL-c were not found to be significant.
Conclusion: Apo B/apo A-I ratio seems to have better predictive value than that of classical lipid parameters in cardiovascular risk assessment.
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